Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 10.1016/j.tibs.2004.06.006 Coxsackievirus B3 infection dysregulates the expression of Hsp70, cyclin E, and p27. VP1 dysregulates the expression of cyclin E and p27, Up-regulated Hsp70 in the cells expressing VP1 results in the dysregulation of cyclin E and p27. Study on the gene expression profile of the cells expressing VP1 showed that the expression of both heat shock protein 70-1 (Hsp70-1) and Hsp70-2 was significantly up-regulated. These are stable identifiers and should be used to cite UniProtKB entries. Immunol. Viruses.

2020 Jan 31;12(2):166. doi: 10.3390/v12020166. 10.1007/978-3-540-75546-3_6 VP1 also inhibited phosphorylation of TPL2 at Thr290, while Thr290 resulted as the key functional site associated with the TPL2-mediated antiviral response. 2020 Apr 9;11:540. doi: 10.3389/fmicb.2020.00540. in UniProtKB/Swiss-Prot.

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Capsid protein VP1 attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells. -, Cao X., Xue L., Han L., Ma L., Chen T., Tong T. (2011). The cell-surface receptors for SV40, mPyV, … Formulation: PBS State: Serum State: Liquid … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Qiu Y, Ye X, Hanson PJ, Zhang HM, Zong J, Cho B, Yang D. Cell Mol Life Sci. We'd like to inform you that we have updated our Privacy Notice to comply NIH VP1 was the only capsid protein detected in these cells. J. Biol.

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
Due to limited sample availability and the difference in protein relative abundances, the characterization of AAV capsid proteins … A Kidnapping Story: How Coxsackievirus B3 and Its Host Cell Interact. The dominant protein …

Manually curated information for which there is published experimental evidence.

Polyomavirus capsids are composed of three proteins; the major component is major capsid protein VP1, which self-assembles into pentamers that in turn self-assemble into enclosed … 1524 3–27. Please consider upgrading. J Clin … TaqMan RT-PCR.  |  A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. AAV Anc80L65 VP1; Sequence of AAV6 Assembly-Activating Protein (AAP) Sequence of AAV4 Assembly-Activating Protein (AAP) Sequence of AAV3B Assembly-Activating Protein (AAP) Sequence of AAV1 Assembly-Activating Protein (AAP) Sequence of AAV9 Assembly-Activating Protein (AAP) Sequence of AAV8 Assembly-Activating Protein … Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Curr. The current subsections and their content are listed below:

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). However, how the structural and non-structural components of CVB would manipulate cell cycle is not clearly understood. 10 The previously co-eluting VP1 and VP2 species were now resolved from VP3, with a third additional peak observed at 12.2 … Epub 2017 Feb 1. Western … Biol. The capsid encapsulate the genomic RNA and VP2 proteins… -, Banfalvi G. (2017). EV-A71 capsid protein VP1 mediates virus attachment and is the important virulence factor in the EV-A71pathogenesis. All positional information in this entry refers to it. Cyclic redundancy and other checksums
J Virol. Enterovirus A71 (EV-A71) is the major cause of severe hand-foot-and-mouth diseases (HFMD), especially encephalitis and other nervous system diseases. from the sequence. the ratio at which VP1, VP2 and VP3 proteins are synthesized in vivo is about 1:1:10, which is the same as in the mature virus particle. Additionally, this section gives relevant information on each alternative protein isoform. (A) Cardiomyocytes were isolated from…, VP1 dysregulates the expression of cyclin E and p27 kip1 . Because of its small genome, CVB depends on cellular machineries for productive replication. Produced by alternative splicing (2.3 kb mRNA), with initiatory methionine encoded by an ACG codon. Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy. G1 arrest was the result of the decrease level of cyclin E and the accumulation of p27 Kip1.

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Clinical application of capsid protein VP1 of EV71 1221. In this study, we demonstrated that the capsid protein VP1 of CVB type 3 (CVB3) induced cell cycle arrest at G1 phase. Please enable it to take advantage of the complete set of features! In this study we found that the VP1 capsid protein of … Heat shock protein 70 promotes coxsackievirus B3 translation initiation and elongation via Akt-mTORC1 pathway depending on activation of p70S6K and Cdc2. (A,B) HeLa…, Up-regulated Hsp70 in the cells expressing VP1 results in the dysregulation of cyclin…, Coxsackievirus B3 infection induces G1…, Coxsackievirus B3 infection induces G1 arrest. Produced by alternative initiation of the 2.3 kb mRNA.

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